INFLUENCE OF GALLIC ACID ON Α-AMYLASE AND Α-GLUCOSIDASE INHIBITORY AND ANTIOXIDANT PROPERTIES OF ACARBOSE

  • Type: Project
  • Department: Bio-Chemistry
  • Project ID: BCH0178
  • Access Fee: ₦5,000 ($14)
  • Pages: 90 Pages
  • Format: Microsoft Word
  • Views: 720
  • Report This work

For more Info, call us on
+234 8130 686 500
or
+234 8093 423 853

ABSTRACT

Type 2 diabetes mellitus (T2DM) is a chronic progressive disease that has continued to be a global heath and economic burden. Acarbose is an antidiabetic drug, which acts by inhibiting alpha amylase and alpha glucosidase; while gallic acid is a simple phenolic acid that is widespread in plant foods and beverages such as tea and wine.This study therefore, sought to investigate the influence of gallic acid on α-amylase and α-glucosidase inhibitory and antioxidant properties of acarbose (in vitro). Aqueous solution of acarbose and gallic acid were prepared to a final concentration of 25µM each. Thereafter, mixtures of the samples (50% acarbose + 50% gallic acid; 75% acarbose + 25% gallic acid; 25% acarbose + 75% gallic acid) were prepared. The results showed that the combination of 50% acarbose and 50% gallic acid showed the highest α-glucosidase inhibitory effect, while 75% acarbose + 25% gallic acid showed highest α- amylase inhibitory effect. Furthermore, all the samples caused the inhibition of Fe2+ -induced lipid peroxidation (in vitro) in rat pancreatic tissue homogenate, with the combination of 50% acarbose and 50% gallic acid causing the highest reduction in the malondialdehyde content. In addition, all the samples showed antioxidant properties (ferric reducing property, 2, 2'-azino-bis (-3-ethylbenzthiazoline-6-sulphonate (ABTS*) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radicals scavenging abilities, and Fe2+ chelating ability). Therefore, the combinations of gallic acid with acarbose could be employed in the management of T2DM with the comparative advantage of possible reduction of the side effects of acarbose; nevertheless the combination of 50% acarbose and 50% gallic acid seems the best combinatory therapy for the management of type 2 diabetes mellitus.

INFLUENCE OF GALLIC ACID ON Α-AMYLASE AND Α-GLUCOSIDASE INHIBITORY AND ANTIOXIDANT PROPERTIES OF ACARBOSE
For more Info, call us on
+234 8130 686 500
or
+234 8093 423 853

Share This
  • Type: Project
  • Department: Bio-Chemistry
  • Project ID: BCH0178
  • Access Fee: ₦5,000 ($14)
  • Pages: 90 Pages
  • Format: Microsoft Word
  • Views: 720
Payment Instruction
Bank payment for Nigerians, Make a payment of ₦ 5,000 to

Bank GTBANK
gtbank
Account Name Obiaks Business Venture
Account Number 0211074565

Bitcoin: Make a payment of 0.0005 to

Bitcoin(Btc)

btc wallet
Copy to clipboard Copy text

500
Leave a comment...

    Details

    Type Project
    Department Bio-Chemistry
    Project ID BCH0178
    Fee ₦5,000 ($14)
    No of Pages 90 Pages
    Format Microsoft Word

    Related Works

    ABSTRACT Type 2 diabetes mellitus (T2DM) is a chronic progressive disease that has continued to be a global heath and economic burden. Acarbose is an antidiabetic drug, which acts by inhibiting alpha amylase and alpha glucosidase; while gallic acid is a simple phenolic acid that is widespread in plant foods and beverages such as tea and wine.This... Continue Reading
    THE INHIBITORY EFFECT OF ETHANOLIC EXTRACT OF MORINGA OLEIFERA LEAF ON THE CORROSION OF MILD STEEL IN 5 M AND 1 M HYDROCHLORIC ACID (HCl)   DEPARTMENT OF PURE AND APPLIED CHEMISTRY   ABSTRACT The extract of Moringa oleifera leaf in aqueous 5 M HCl and 1 M HCl was systematically investigated to ascertain its inhibitory effect on the corrosion of... Continue Reading
    (CITRUS SINENSIS) ABSTRACT The effect of different consecrations of citric acid on the physicochemical properties of orange juice was studied. Four samples of the orange juice were prepared, three of which were added (O.ICA), O.2 (B) and 0.3%... Continue Reading
    ABSTRACT The effect of different consecrations of citric acid on the physicochemical properties of orange juice was studied. Four samples of the orange juice were prepared, three of which were added (O.ICA), O.2 (B) and 0.3%... Continue Reading
    PIPE GUIEENSE (UZIZA) XYLPIA AETHPICA (UDA) MONODORA MYRISTICA (EHURU) TETRAPELURA TETRAPTERA (OSHOSHO) Abstract a comparative study was done on the physico-chemical and antioxidant properties of some culinary herbs and local spices. Piper Guiness (Uziza), Xylopia... Continue Reading
    Abstract a comparative study was done on the physico-chemical and antioxidant properties of some culinary herbs and local spices. Piper Guiness (Uziza), Xylopia aethopica (Uda), Monodora Myristica (Ehuru) and TrtraleuraTetraopera (Oshsho).  The proximate analysis of these spices  were done to determine their moisture content, ash... Continue Reading
    Morinda lucida is a tropical West African evergreen shrub or small to medium sized rainforest tree, having brown colored bark, white flowers and yellowish ellipsoid seeds. It is widely used in traditional medicine systems of different countries. This study was designed to carry out the preliminary phytochemical screening and evaluation antioxidant... Continue Reading
    Morinda lucida is a tropical West African evergreen shrub or small to medium sized rainforest tree, having brown colored bark, white flowers and yellowish ellipsoid seeds. It is widely used in traditional medicine systems of different countries. This study was designed to carry out the preliminary phytochemical screening and evaluation antioxidant... Continue Reading
    ABSTRACT Azadirachta indica, commonly known as Neem, has attracted worldwide prominence in recent years as a cynosure of modern medicine owing to its wide range of medicinal properties. This study was carried out to investigate the phytochemical properties and antioxidant activity of the multi-solvent (methanol, ethanol and hexane) extracts of the... Continue Reading
    ABSTRACT Azadirachta indica, commonly known as Neem, has attracted worldwide prominence in recent years as a cynosure of modern medicine owing to its wide range of medicinal properties. This study was carried out to investigate the phytochemical properties and antioxidant activity of the multi-solvent (methanol, ethanol and hexane) extracts of the... Continue Reading
    Call Us
    whatsappWhatsApp Us