Immunomodulatory Potentials of Ethanolic Leaf Extract of Phyllantus amarus in Wistar Rats
Abstract
The immunomodulatory effect of the ethanolic leaf extract of Phyllantus amarus on wistar rats was investigated. Twenty eight (28) male animals were used for the study. The animals were divided into four (4) groups of seven (7) animals each. Group 1 was the normal control and received distilled water, animals in group 2 were given low dose (7.1 mg/kgBW) of the extract, group 3 were given medial dose (14.1mg/kgBW) and group 4 were given high dose (28.3 mg/kgBW) of the extract. The treatment was administered twice daily for twenty eight (28) days after which the animals were sacrificed and blood samples used for analysis where obtained via cardiac puncture. The phytochemical screening of the plant was carried out and results shows that the plant contains flavonoids, saponins, alkaloids, terpenes, phenols, steroids, glycosides and tannin. Results reveal that the group treated with low (102.41±7.41), medial (101.84±11.72) and high dose (100.94±30.47) recorded an elevated WBC value when compared with the control (83.20±11.30) at p
